i havent slept in bout 4 days and doctor wants me on unisom and zypran to help me sleep and quit smoking... is it safe?

If your OB told you that taking it will help you sleep, then odds are that it's safe. Check with the pharmacist if you aren't sure, though. Or call a different OB for a second opinion. I don't know about Zypran, but I've taken Unisom during pregnancy and while nursing before and it didn't seem to have any negative effects on the baby. She actually was a little less active at night, but otherwise was fine. And she woke me bright and early about 8 1/2 hours after I took the pill with lots of activity - and noise after she was born.