I am in the same boat. I got a call that my quad screen came back with a positive for spina bifida. They said my chances went from the normal "1 in 800" chance, to "1 in 257" chance. I suppose those are still pretty good odds, but I can't help but freak out a bit. It's scary to recieve that news, and I feel so helpless. The good news is that there are MANY false positives- although I don't care about any of the others, I just want to know about mine. Other considerations are that many cases of spina bifida are correctable by surgery, either in utero, or shortly after birth. Here are some numbers that should make you feel better. My husband did a little research to calm me down from that phone call... 1 in 12 women get a positive result from those screen tests. Out of those positives, over 90% go on to have perfectly healthy babies. Although its a scare, the numbers really are on our side. Makes me wonder why I agreed to do this stress causer in the first place. I have my ultrasound tomorrow, where they will take a very close look at the baby's spine. That should tell us more. I will keep you posted!